tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

Base Information

Chemical Name:tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane
CAS No.:1067880-35-6
Molecular Formula:C₂₄H₃₄O₅Si
Molecular Weight:430.616
Hs Code.:

Synonyms:tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

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Chemical Property of tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

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Technology Process of tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

There total 10 articles about tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2065-66-9
methyl-triphenylphosphonium iodide

: 203448-30-0
(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone

: 1067880-35-6
tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

Guidance literature:: methyl-triphenylphosphonium iodide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2017.07.048

Reference yield: 55.0%

: 1136-86-3
methyl (3,4,5-trimethoxyphenyl) ketone

: 186837-48-9
3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide

: 1067880-35-6
tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

Guidance literature:: 3-(tert-butyldimethylsilyloxy)-4-methyloxyphenyl iodide; With tert.-butyl lithium; In hexane; at -78 ℃; for 0.75h;

methyl (3,4,5-trimethoxyphenyl) ketone; In hexane; toluene; for 12h;

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 1067880-35-6
tert-butyl(2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)vinyl)phenoxy)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 24 h / -78 - 20 °C / Inert atmosphere

3.1: dipyridinium dichromate / dichloromethane / 0 °C / Molecular sieve

4.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.2: 24 h / -78 - 20 °C / Inert atmosphere

With dipyridinium dichromate; n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1016/j.bmc.2017.07.048