(2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Chemical Name:(2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.:1189570-33-9
Molecular Formula:C₃₃H₃₂F₂N₄O₂
Molecular Weight:554.639
Hs Code.:

Synonyms:(2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Chemical Property of (2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Technology Process of (2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

There total 10 articles about (2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189570-34-0
tert-butyl (8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-9-[(2E)-3-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)prop-2-en-1-yl]-6,9-diazaspiro[4,5]decane-6-carboxylate

: 1189570-33-9
(2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

: 1189569-02-5
(2R)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: tert-butyl (8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-9-[(2E)-3-(2'-oxo-1'-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl)prop-2-en-1-yl]-6,9-diazaspiro[4,5]decane-6-carboxylate; With trifluoroacetic acid; In dichloromethane; for 24h;

With ethylenediamine; sodium hydroxide; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 879132-46-4
1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine

: 1189570-33-9
(2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

2.1: water

3.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

4.1: caesium carbonate / methanol / 18 h

5.1: sodium acetate / tris(o-methoxyphenyl)phosphine; palladium diacetate / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 24 h

6.2: 0.5 h / 20 °C

With water; sodium acetate; pyridinium hydrobromide perbromide; ammonium chloride; caesium carbonate; trifluoroacetic acid; zinc; tris(o-methoxyphenyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 271-63-6
7-Azaindole

: 1189570-33-9
(2S)-5-{(1E)-3-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]prop-1-en-1-yl}-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.42 h / 0 °C

1.2: 1.25 h / 10 °C

2.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 1 h / 20 °C

3.1: water

4.1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h

5.1: caesium carbonate / methanol / 18 h

6.1: sodium acetate / tris(o-methoxyphenyl)phosphine; palladium diacetate / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 24 h

7.2: 0.5 h / 20 °C

With water; sodium acetate; pyridinium hydrobromide perbromide; sodium hydride; ammonium chloride; caesium carbonate; trifluoroacetic acid; zinc; tris(o-methoxyphenyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;