2-CHLORO-1H-BENZIMIDAZOLE-6-METHANOL

Base Information

• Chemical Name: 2-CHLORO-1H-BENZIMIDAZOLE-6-METHANOL
• CAS No.: 857070-66-7
• Molecular Formula: C₈H₇ClN₂O
• Molecular Weight: 182.609
• Mol file: 857070-66-7.mol

Synonyms:1H-Benzimidazole-5-methanol,2-chloro- (9CI); (2-Chloro-3H-benzimidazol-5-yl)methanol

Chemical Property of 2-CHLORO-1H-BENZIMIDAZOLE-6-METHANOL

Chemical Property:

• Melting Point: 179 °C
• Boiling Point: 432.5±37.0 °C(Predicted)
• PKA: 9.52±0.10(Predicted)
• Density: 1.510±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

2-CHLORO-1H-BENZIMIDAZOLE-6-METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-1H-BENZIMIDAZOLE-6-METHANOL

There total 3 articles about 2-CHLORO-1H-BENZIMIDAZOLE-6-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-chloro-3H-benzoimidazole-5-carboxylic acid ethyl ester (857035-29-1) → (2-chloro-3H-benzoimidazol-5-yl)methanol (857070-66-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 ℃; for 3h;

DOI:10.1021/jm701284j

Reference yield: 95.0%

2-hydroxy-3H-benzoimidazole-5-carboxylic acid ethyl ester (634602-84-9) → (2-chloro-3H-benzoimidazol-5-yl)methanol (857070-66-7)

Guidance literature:

2-hydroxy-3H-benzoimidazole-5-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 ℃; for 3h;

With water; In tetrahydrofuran;

Reference yield:

ethyl 3,4-diaminobenzoate (37466-90-3) → (2-chloro-3H-benzoimidazol-5-yl)methanol (857070-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene / 12 h / Heating / reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 5 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; xylene;

upstream raw materials:

2-chloro-3H-benzoimidazole-5-carboxylic acid ethyl ester

2-hydroxy-3H-benzoimidazole-5-carboxylic acid ethyl ester

ethyl 3,4-diaminobenzoate

Downstream raw materials:

[2-(3-morpholin-4-ylpropylamino)-3H-benzoimidazol-5-yl]methanol

3-(3-hydroxy-6-methylpyridin-2-ylmethyl)-2-(3-morpholin-4-ylpropylamino)-3H-benzoimidazole-5-carbaldehyde

2-[5-hydroxymethyl-2-(3-morpholin-4-ylpropylamino)benzoimidazol-1-ylmethyl]-6-methylpyridin-3-ol

2-[6-hydroxymethyl-2-(3-morpholin-4-ylpropylamino)benzoimidazol-1-ylmethyl]-6-methylpyridin-3-ol