N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine

Base Information

• Chemical Name: N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine
• CAS No.: 858343-58-5
• Molecular Formula: C₂₄H₂₈N₄O
• Molecular Weight: 388.513
• Mol file: 858343-58-5.mol

Synonyms:N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine

Chemical Property of N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine

Chemical Property:

Purity/Quality:

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Technology Process of N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine

There total 1 articles about N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(N-benzylaminomethyl)pyridine (18081-89-5) + N-(6-(bromomethyl)-2-pyridyl)pivalamide (111477-43-1) → N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine (858343-58-5)

Guidance literature:

With tetrabutylammomium bromide; sodium carbonate; In acetonitrile; for 22h; Heating;

DOI:10.1039/b500534e

Reference yield: 84.0%

N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine (858343-58-5) + methanol (67-56-1) + manganese(II) perchlorate hexahydrate + tetramethlyammonium chloride (75-57-0) → [(N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridylmethyl)amine)Mn(Cl)(methanol)]ClO4 (882530-14-5)

Guidance literature:

In methanol; byproducts: (CH3)4NClO4; a soln. of Mn salt added to a soln. of ligand, stirred for ca 15 min, added to a slurry of (CH3)4NCl, stirred overnight; evapd. (vac.), dissolved in MeOH, filtered, evapd. (vac.), recrystd. from MeOH via Et2O diffusion;

DOI:10.1016/j.ica.2005.09.008

Reference yield: 78.0%

N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine (858343-58-5) + manganese(II) perchlorate hexahydrate + sodium oxalate (62-76-0) → [((N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridyl-methyl)amine)Mn)2(μ-oxalato)](ClO4)2

Guidance literature:

In methanol; (N2); a soln. of Mn salt added to a soln. of C24H28N4O, stirred for ca. 20 min at ambient temp., Na2C2O4 added, stirred for 6 d; evapd. (vac.), dissolved in CH2Cl2, filtered, evapd. (vac.), recrystd. (MeCN/Et2O, -20°C); elem. anal.;

DOI:10.1039/b500534e

upstream raw materials:

2-(N-benzylaminomethyl)pyridine

N-(6-(bromomethyl)-2-pyridyl)pivalamide

Downstream raw materials:

[(N-benzyl-N-((6-pivaloylamido-2-pyridyl)methyl)-N-(2-pyridylmethyl)amine)Mn(Cl)(methanol)]ClO₄

Refernces