(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

Base Information

Chemical Name:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride
CAS No.:1196504-51-4
Molecular Formula:C₁₉H₁₉BrFN₅O*ClH
Molecular Weight:468.756
Hs Code.:

Synonyms:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

There total 7 articles about (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₇BrFN₅O₃

: 1196504-51-4
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

Guidance literature:: C₂₄H₂₇BrFN₅O₃; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 1172067-95-6
5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine

: 1196504-51-4
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: nitric acid / 0.5 h / 0 °C

2.1: hydrogenchloride; tin(ll) chloride / 0 - 20 °C

2.2: pH 7

3.1: pyridine / 0.17 h / 20 °C

3.2: 0.33 h

4.1: butan-1-ol / 24 h / Heating

5.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; hydrogenchloride; nitric acid; trifluoroacetic acid; tin(ll) chloride; In dichloromethane; butan-1-ol;

Reference yield:

: 640735-25-7
4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine

: 1196504-51-4
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-fluorobenzamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -78 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

3.1: nitric acid / 0.5 h / 0 °C

4.1: hydrogenchloride; tin(ll) chloride / 0 - 20 °C

4.2: pH 7

5.1: pyridine / 0.17 h / 20 °C

5.2: 0.33 h

6.1: butan-1-ol / 24 h / Heating

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With pyridine; hydrogenchloride; tetrabutyl ammonium fluoride; sec.-butyllithium; nitric acid; trifluoroacetic acid; tin(ll) chloride; In tetrahydrofuran; dichloromethane; cyclohexane; butan-1-ol;