ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Base Information

Chemical Name:ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate
CAS No.:1350469-24-7
Molecular Formula:C₂₄H₂₇N₃O₆
Molecular Weight:453.495
Hs Code.:

Synonyms:ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

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Chemical Property of ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

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Technology Process of ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

There total 12 articles about ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1350469-23-6
ethyl (1R)-1-({2-[3-(dimethylcarbamoyl)-4-nitrophenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

: 1350469-24-7
ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Guidance literature:: With iron; acetic acid; In ethanol; for 1h; Reflux;

Reference yield:

: 89-51-0
Homophthalic acid

: 1350469-24-7
ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / 24 h / 75 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 20 h / 80 °C

3: acetonitrile; tetrahydrofuran / 20.5 h / 0 - 40 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 1 h / 20 °C

5: Chiralpak AS-H 4.6x250 mm column / carbon dioxide; methanol / Resolution of racemate; Chiral SFC

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

7: acetic acid; iron / ethanol / 1 h / Reflux

With dmap; N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; carbon dioxide; acetonitrile;

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 1350469-24-7
ethyl (1R)-1-({2-[4-amino-3-(dimethylcarbamoyl)phenyl]acetoxy}methyl)-2-methyl-3-oxoisoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 1 h / Reflux

2.1: triethylamine / tetrahydrofuran / 20 °C / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

3.2: 3 h / 120 °C

4.1: hydrogenchloride; water / 3 h / Reflux

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

6.1: acetic acid; iron / ethanol / 1 h / Reflux

With hydrogenchloride; dmap; water; iron; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;