N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

Base Information

Chemical Name:N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine
CAS No.:615268-39-8
Molecular Formula:C₃₃H₄₂N₂O₅
Molecular Weight:546.707
Hs Code.:

Synonyms:N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

Chemical Property:

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Technology Process of N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

There total 6 articles about N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 79-46-9
2-nitropropane

: 615268-38-7
4-[N-benzyl-N-(tert-butyloxycarbonyl)]amino-3,3-dibenzyl-butanal

: 615268-39-8
N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

Guidance literature:: With potassium tert-butylate; at 20 ℃; for 12h;
DOI:10.1021/ol035564x

Reference yield:

: 57772-73-3
ethyl 2-benzyl-3-phenylpropionate

: 615268-39-8
N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: LDA / tetrahydrofuran / 0.75 h / -78 °C

1.2: 89 percent / tetrahydrofuran / 2.5 h / -78 - 0 °C

2.1: 95 percent / LiAlH₄ / diethyl ether / 12 h / Heating

3.1: 5.23 g / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

4.1: 4.84 g / sodium cyanoborohydride; CH₃CO₂H / methanol / 2 h / 20 °C

5.1: 96 percent / triethylamine / CH₂Cl₂ / 19 h / 20 °C

6.1: O₃ / CH₂Cl₂ / -78 °C

6.2: 34 percent / Ph₃P / CH₂Cl₂ / 20 °C

7.1: 54 percent / potassium tert-butoxide / 12 h / 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; sodium cyanoborohydride; ozone; acetic acid; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 3.1: Swern oxidation / 7.1: Henry reaction;
DOI:10.1016/j.tet.2006.03.063

Reference yield:

: 615268-34-3
2,2-dibenzyl-pent-4-en-1-ol

: 615268-39-8
N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-hydroxy-5-methyl-5-nitro-hexylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 5.23 g / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / 1.33 h / cooling

2.1: 4.84 g / sodium cyanoborohydride; CH₃CO₂H / methanol / 2 h / 20 °C

3.1: 96 percent / triethylamine / CH₂Cl₂ / 19 h / 20 °C

4.1: O₃ / CH₂Cl₂ / -78 °C

4.2: 34 percent / Ph₃P / CH₂Cl₂ / 20 °C

5.1: 54 percent / potassium tert-butoxide / 12 h / 20 °C

With oxalyl dichloride; potassium tert-butylate; sodium cyanoborohydride; ozone; acetic acid; dimethyl sulfoxide; triethylamine; In methanol; dichloromethane; 1.1: Swern oxidation / 5.1: Henry reaction;
DOI:10.1016/j.tet.2006.03.063