diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

Base Information

Chemical Name:diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate
CAS No.:1365769-41-0
Molecular Formula:C₃₀H₃₅BO₈
Molecular Weight:534.414
Hs Code.:

Synonyms:diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

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Chemical Property of diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

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Technology Process of diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

There total 2 articles about diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1365769-33-0
4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzaldehyde

: 105-53-3
diethyl malonate

: 1365769-41-0
diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

Guidance literature:: With piperidine; In acetonitrile; at 60 ℃; for 15h; Molecular sieve;
DOI:10.1021/ja3004045

Reference yield:

: 67268-54-6
2-hydroxy-4-(prop- 2-yn-1-yloxy)benzaldehyde

: 138500-85-3
4-bromomethylphenylboronic acid pinacol ester

: 1365769-41-0
diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 17 h / 60 °C

2: piperidine / acetonitrile / 15 h / 60 °C / Molecular sieve

With piperidine; potassium carbonate; In acetonitrile;
DOI:10.1021/ja3004045

Reference yield:

: 1365769-41-0
diethyl 2-(4-(prop-2-ynyloxy)-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyloxy)benzylidene)malonate

: 1365769-29-4
Eu(C₈H₁₆(NCH₂CO₂)3NCH₂CONHC₂H₄N₃)

: 1365769-49-8
Eu(C₈H₁₆(NCH₂CO₂)3NCH₂CONHC₂H₄N₃C₂HCH₂OC₆H₃(OCH₂C₆H₄BO₂C₂(CH₃)4)CHC(CO₂C₂H₅)2)

Guidance literature:: With catalyst:CuSO₄, Na-ascorbate, NH₂C(C₂HN₃CH₂C₆H₅)3; In tetrahydrofuran; water; tert-butyl alcohol; CuSO4, Na-ascorbate, tris((1-benzyl-1H-1,2,3-triazol-4-yl)methylamine, H2O/C(CH3)3OH/THF 2:1:1;
DOI:10.1021/ja3004045