(S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid

Base Information

Chemical Name:(S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid
CAS No.:208775-75-1
Molecular Formula:C₁₆H₁₈N₂O₅S₂
Molecular Weight:382.461
Hs Code.:

Synonyms:(S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid

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Chemical Property of (S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid

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Technology Process of (S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid

There total 2 articles about (S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 108197-21-3
4-[(thiophene-2-carbonyl)-amino]-benzenesulfonyl chloride

: 208775-75-1
(S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 2h;
DOI:10.1007/BF02251685

Reference yield:

: 6846-13-5
N-phenyl-2-thiophenecarboxamide

: 208775-75-1
(S)-3-Methyl-2-{4-[(thiophene-2-carbonyl)-amino]-benzenesulfonylamino}-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / chlorosulfonic acid / 40 °C

2: 78 percent / Et₃N / tetrahydrofuran; H₂O / 2 h / 20 °C

With chlorosulfonic acid; triethylamine; In tetrahydrofuran; water;
DOI:10.1007/BF02251685