1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

Base Information

Chemical Name:1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide
CAS No.:1446862-57-2
Molecular Formula:C₂₆H₂₆N₃O*I
Molecular Weight:523.416
Hs Code.:

Synonyms:1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

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Chemical Property of 1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

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Technology Process of 1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

There total 9 articles about 1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1446863-03-1
2-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxaline

: 74-88-4
methyl iodide

: 1446862-57-2
1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

Guidance literature:: at 60 ℃; regioselective reaction; Sealed tube;
DOI:10.1016/j.bmcl.2013.06.048

Reference yield:

: 188813-07-2
methyl 3-bromo-5-iodobenzoate

: 1446862-57-2
1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

6: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C

7: 60 °C / Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; lithium hydroxide monohydrate; potassium acetate; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.06.048

Reference yield:

: 123324-71-0
p-tert-butylphenylboronic acid

: 1446862-57-2
1-methyl-3-[[1,1'-biphenyl-5-(aminocarbonyl)-4’-(t-butyl)]-3-yl]quinoxalinium iodide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3 h / 100 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 80 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 100 °C

4: lithium hydroxide monohydrate / water; tetrahydrofuran / 50 °C

5: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

6: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C

7: 60 °C / Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; lithium hydroxide monohydrate; potassium acetate; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.06.048