4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile

Base Information

• Chemical Name: 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile
• CAS No.: 1228319-82-1
• Molecular Formula: C₂₇H₁₇ClN₄S
• Molecular Weight: 464.978

Synonyms:4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile

Chemical Property of 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile

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Technology Process of 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile

There total 1 articles about 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Cyanothioacetamide (7357-70-2) + 3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1-phenylpropenone (380450-07-7) → 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (1228319-82-1)

Guidance literature:

With piperidine; In ethanol; for 4h; Reflux;

DOI:10.1080/10426500902814049

Reference yield: 73.0%

4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (1228319-82-1) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-({4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-cyano-6-phenylpyridin-2-yl}thio)acetate (1228319-83-2)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Reflux;

DOI:10.1080/10426500902814049

Reference yield: 73.0%

4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile (1228319-82-1) + methyl iodide (74-88-4) → 4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-6-phenyl-2-methylthionicotinonitrile (1228320-03-3)

Guidance literature:

With sodium methylate; In methanol; for 2h; Reflux;

DOI:10.1080/10426500902814049

upstream raw materials:

Cyanothioacetamide

3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-1-phenylpropenone

Downstream raw materials:

4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2-[(cyanomethyl)thio]-6-phenylnicotinonitrile

3-amino-4-[(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)]-6-phenylthieno[2,3-b]pyridine-2-carbonitrile

ethyl 2-({4-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-cyano-6-phenylpyridin-2-yl}thio)acetate

ethyl 3-amino-4-[(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)]-6-phenylthieno[2,3-b]pyridine-2-carboxylate

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