6-FLUORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 6-FLUORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE
• CAS No.: 852660-54-9
• Molecular Formula: C10H12 F N . Cl H
• Molecular Weight: 201.671
• Mol file: 852660-54-9.mol

Synonyms:2-Naphthalenamine,6-fluoro-1,2,3,4-tetrahydro-, hydrochloride (9CI)

Chemical Property of 6-FLUORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 26.02000
• LogP: 3.14400

Purity/Quality:

98% ^*data from raw suppliers

6-Fluoro-1,2,3,4-tetrahydro-naphthalen-2-ylaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE

There total 2 articles about 6-FLUORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-2-YLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

6-fluoro-3,4-dihydronaphthalen-2(1H)-one oxime (852660-53-8) → 6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (852660-54-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; for 18h; under 3604.44 Torr;

Reference yield:

6-fluoro-2-tetralone (29419-14-5) → 6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (852660-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.5 h / 20 °C

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / methanol; water / 18 h / 3604.44 Torr

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; palladium 10% on activated carbon; In methanol; ethanol; water;

Reference yield: 69.0%

(1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde (275815-60-6) + 6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride (852660-54-9) → benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate (852660-55-0)

Guidance literature:

(1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde; 6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; With triethylamine; In 1,2-dichloro-ethane;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 3.5h;

upstream raw materials:

6-fluoro-3,4-dihydronaphthalen-2(1H)-one oxime

6-fluoro-2-tetralone

Downstream raw materials:

benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate

N-{[(1S,2R)-2-aminocyclohexyl]methyl}-(2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine

N-(2RS)-{[(1S,2R)-2-aminocyclohexyl]methyl}-6-fluoro-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine

benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate