29419-14-5

Basic information

• Product Name: 6-Fluoro-2-tetralone
• Synonyms: 6-FLUORO-3,4-DIHYDRO-1H-NAPHTHALEN-2-ONE;6-Fluoro-3,4-dihydronaphthalen-2(1H)-one;6-Fluoro-2-tetralone;2(1H)-Naphthalenone, 6-fluoro-3,4-dihydro-
• CAS NO: 29419-14-5
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• Product Categories: pharmacetical
• Mol File: 29419-14-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 265.5 °C at 760 mmHg
• Flash Point: 101.4 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 0.034mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 6-Fluoro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-2-tetralone(29419-14-5)
• EPA Substance Registry System: 6-Fluoro-2-tetralone(29419-14-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-52
• Hazardous Substances Data: 29419-14-5(Hazardous Substances Data)

Usage

General Description

6-Fluoro-2-tetralone is a chemical compound with the molecular formula C10H9FO. It is a fluorinated derivative of tetralone, which is used as a precursor in the synthesis of various pharmaceuticals and other organic compounds. The fluoro substituent in 6-Fluoro-2-tetralone imparts unique chemical and biological properties, making it useful in medicinal chemistry and pharmacology. The compound has been studied for its potential anti-inflammatory and analgesic properties, and it is also used as a building block in the synthesis of diverse organic molecules. 6-Fluoro-2-tetralone is commercially available and is used as a research chemical in the pharmaceutical industry.

InChI:InChI=1/C9H7FO/c10-8-2-1-6-4-9(11)5-7(6)3-8/h1-3H,4-5H2

Upstream product

• 74-85-1 ethene 
• 405-50-5 p-Fluorophenylacetic acid 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-22-3 4-fluorophenylacetonitrile 
• 352-32-9 p-fluorotoluene 

Downstream Products

• 85072-31-7 6-fluorotetralin-2-ol 
• 852660-52-7 N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)urea 
• 852660-57-2 N-[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]-N'-((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)urea 
• 852660-55-0 benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]methyl}cyclohexyl)carbamate 
• 852660-58-3 benzyl ((1R,2S)-2-{[((2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl)(methyl)amino]methyl}cyclohexyl)carbamate 
• 852660-54-9 6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride 
• 852660-59-4 N-(2RS)-{[(1S,2R)-2-aminocyclohexyl]methyl}-6-fluoro-N-methyl-1,2,3,4-tetrahydronaphthalen-2-amine 
• 852660-56-1 N-{[(1S,2R)-2-aminocyclohexyl]methyl}-(2RS)-6-fluoro-1,2,3,4-tetrahydronaphthalen-2-amine 
• 581-72-6 2-bromomethyl-6-fluoronaphthalene 
• 66922-61-0 (6-fluoro-naphthalene-2-yl)-acetonitrile 
• 324-42-5 2-fluoro-6-methylnaphthalene 
• 247936-75-0 3,4-dihydro-6-fluoro-1-(phenylmethyl)-2(1H) naphthalenone 

Relevant articles and documents

Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H- benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes

A series of 1-, 3-, and 4-substituted analogs to the potent 5-HT(1A) agonist 8-(dipropylamino)6,7,8,9-tetrahydro-3H-benz[e]indole-1-carbaldehyde (5) were prepared and tested in vitro at 5-HT(1A), 5-HT(1Dα), 5-HT(1Dβ), D2, and D3 rece

Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.

The synthesis of novel cis-α-substituted-β-aminotetralins

Teteralones were converted, in 1 to 3 steps, to α-substituted tetralones. Subsequent reductive amination with ammonium acetate/sodium cyanoborohydride gave the corresponding α-substituted-β-aminotetralins, on a multigram scale, with minimal chromatography for the entire transformation.