N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide
CAS No.:1356920-07-4
Molecular Formula:C₃₆H₂₉F₄N₅O₅S
Molecular Weight:719.716
Hs Code.:

N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

Synonyms:N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

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Chemical Property of N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

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Technology Process of N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

There total 4 articles about N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356920-06-3
3-[(3S,4S)-4-(4-aminophenyl)-3-{[(4S)-4-benzyl-2-oxo1,3-thiazolidin-3-yl]carbonyl}-4-hydroxybutyl]-1,2,3-benzotriazin-4(3H)-one

: 126917-10-0
2-fluoro-4-(trifluoromethyl)benzoyl chloride

: 1356920-07-4
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1008742-67-3
3-{4-[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]-4-oxobutyl}-1,2,3-benzotriazin-4(3H)-one

: 1356920-07-4
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 - 25 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

1.3: 2 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 25 °C / 2585.81 Torr / Parr apparatus

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogen; titanium tetrachloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1356920-07-4
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 - 25 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

1.3: 2 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 25 °C / 2585.81 Torr / Parr apparatus

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogen; titanium tetrachloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;