(2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Chemical Name:(2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid
CAS No.:1356919-73-7
Molecular Formula:C₂₆H₂₀F₄N₄O₅
Molecular Weight:544.462
Hs Code.:

Synonyms:(2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Chemical Property of (2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Technology Process of (2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

There total 5 articles about (2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356920-07-4
N-{4-[(1S,2S)-2-{[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]carbonyl}-1-hydroxy-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butyl]phenyl}-2-fluoro-4-(trifluoromethyl)benzamide

: 1356919-73-7
(2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield:

: 1008742-67-3
3-{4-[(4S)-4-benzyl-2-oxo-1,3-thiazolidin-3-yl]-4-oxobutyl}-1,2,3-benzotriazin-4(3H)-one

: 1356919-73-7
(2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 - 25 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

1.3: 2 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 25 °C / 2585.81 Torr / Parr apparatus

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 1 h / 20 °C

With hydrogen; dihydrogen peroxide; titanium tetrachloride; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1356919-73-7
(2S)-2-[(S)-(4-{[(3-chloro-2,6-difluorophenyl)carbonyl]amino}phenyl)(hydroxy)methyl]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / 0 - 25 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

1.3: 2 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1 h / 25 °C / 2585.81 Torr / Parr apparatus

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 1 h / 20 °C

With hydrogen; dihydrogen peroxide; titanium tetrachloride; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water;