4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

Base Information

Chemical Name:4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one
CAS No.:1194731-78-6
Molecular Formula:C₂₃H₂₂ClN₃O
Molecular Weight:391.9
Hs Code.:

Synonyms:4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

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Chemical Property of 4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

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Technology Process of 4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

There total 8 articles about 4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1-(1-azetidin-3-yl-2,3-dihydro-1H-indol-5-yl)-4-(4-chloro-phenyl)-1H-pyridin-2-one trifluoroacetate

: 1194731-78-6
4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; water; at 20 ℃; for 0.333333h;

Reference yield:

: 22190-33-6
5-bromoindoline

: 1194731-78-6
4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dichloromethane / Inert atmosphere

4: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.020

Reference yield:

: 1194732-22-3
3-(5-bromo-2,3-dihydro-indol-1-yl)-azetidine-1-carboxylic acid tert-butyl ester

: 1194731-78-6
4-(4-chloro-phenyl)-1-[1-(1-methyl-azetidin-3-yl)-2,3-dihydro-1H-indol-5-yl]-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / Inert atmosphere

3: copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.07.020