2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione
CAS No.:956235-64-6
Molecular Formula:C₂₉H₃₈N₂O₃S
Molecular Weight:494.698
Hs Code.:

Synonyms:2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

There total 9 articles about 2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 956235-63-5
[3-(cyclopentylthio)benzyl]methylamine

: 956234-36-9
2-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]oxy}ethyl methanesulfonate

: 956235-64-6
2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 17h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956235-64-6
2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 5 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 3 h / 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2070.21 Torr

4: triethylamine / dichloromethane / 20 °C

5: sodium hydrogencarbonate / N,N-dimethyl-formamide / 17 h / 70 °C

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 956235-14-6
methyl 3-(cyclopentylthio)benzoate

: 956235-64-6
2-(6-{2-[[3-(cyclopentylthio)benzyl](methyl)amino]ethoxy}hexyl)-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / chloroform / 74.25 h / 0 - 20 °C

3.1: tetrahydrofuran / 2 h / -30 - 20 °C

4.1: borane-THF / tetrahydrofuran / 20 °C / Heating / reflux

5.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 17 h / 70 °C

With lithium hydroxide; borane-THF; oxalyl dichloride; water; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;