3-N-BOC-AMINO-6-PHENYLPYRIDINE

Base Information

• Chemical Name: 3-N-BOC-AMINO-6-PHENYLPYRIDINE
• CAS No.: 849353-27-1
• Molecular Formula: C16H18 N2 O2
• Molecular Weight: 270.331
• Hs Code.: 2933399090
• Mol file: 849353-27-1.mol

Synonyms:3-N-BOC-AMINO-6-PHENYLPYRIDINE

Chemical Property of 3-N-BOC-AMINO-6-PHENYLPYRIDINE

Chemical Property:

• Boiling Point: 364.6±30.0 °C(Predicted)
• PKA: 12.71±0.70(Predicted)
• PSA: 51.22000
• Density: 1.140±0.06 g/cm3(Predicted)
• LogP: 4.16860

Purity/Quality:

98% ^*data from raw suppliers

tert-Butyl(6-phenylpyridin-3-yl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-N-BOC-AMINO-6-PHENYLPYRIDINE

There total 2 articles about 3-N-BOC-AMINO-6-PHENYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-nitro-6-phenylpyridine (89076-64-2) → (6-phenylpyridin-3-yl)carbamic acid ter-butyl ester (849353-27-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 18h; under 2585.81 Torr;

Reference yield: 68.0%

tert-butyl (6-bromopyridin-3-yl)carbamate (218594-15-1) + phenylboronic acid (98-80-6) → (6-phenylpyridin-3-yl)carbamic acid ter-butyl ester (849353-27-1)

Guidance literature:

With potassium carbonate; dichlorobis(chlorodi-tert-butylphosphine) palladium(II); In tetrahydrofuran; methanol; at 20 - 70 ℃; for 1h;

Reference yield: 11.0%

(6-phenylpyridin-3-yl)carbamic acid ter-butyl ester (849353-27-1) → (4-iodo-6-phenylpyridin-3-yl)carbamic acid ter-butyl ester (941271-13-2)

Guidance literature:

(6-phenylpyridin-3-yl)carbamic acid ter-butyl ester; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -78 ℃; for 0.25h;

at -10 ℃; for 3h;

With iodine; In tetrahydrofuran; diethyl ether; at -78 ℃; for 2h;

upstream raw materials:

di-tert-butyl dicarbonate

3-nitro-6-phenylpyridine

tert-butyl (6-bromopyridin-3-yl)carbamate

phenylboronic acid

Downstream raw materials:

(4-iodo-6-phenylpyridin-3-yl)carbamic acid ter-butyl ester