89076-64-2

Basic information

• Product Name: 5-NITRO-2-PHENYLPYRIDINE
• Synonyms: 5-NITRO-2-PHENYLPYRIDINE;5-NITRO-2-METHYLANISOLE;(5-Nitropyridin-2-yl)benzene;3-Nitro-6-phenylpridine
• CAS NO: 89076-64-2
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Mol File: 89076-64-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 116-118°
• Boiling Point: 344.1 °C at 760 mmHg
• Flash Point: 161.9 °C
• Appearance: /
• Density: 1.252 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-NITRO-2-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-NITRO-2-PHENYLPYRIDINE(89076-64-2)
• EPA Substance Registry System: 5-NITRO-2-PHENYLPYRIDINE(89076-64-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 89076-64-2(Hazardous Substances Data)

Usage

General Description

5-Nitro-2-phenylpyridine is a chemical compound with the molecular formula C11H8N2O2. It is a nitroaromatic compound that contains a pyridine ring and a phenyl group. 5-NITRO-2-PHENYLPYRIDINE is used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and other functional materials. It is also used as a reagent in chemical reactions to introduce the 5-nitro-2-phenylpyridine moiety into target molecules. The nitro group in this compound makes it reactive and allows it to participate in various chemical reactions like nitration, reduction, and coupling reactions, making it an important intermediate in the synthesis of various organic compounds.

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 98-80-6 phenylboronic acid 
• 4487-59-6 2-bromo-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 100-58-3 phenylmagnesium bromide 
• 30651-24-2 5-nitropicolinic acid 
• 71-43-2 benzene 
• 4747-13-1 α-methoxystyrene 
• 3433-56-5 1-(1-phenylvinyl)pyrrolidine 
• 603-33-8 triphenylbismuthane 
• 108-86-1 bromobenzene 
• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 98-86-2 acetophenone 

Downstream Products

• 1332586-73-8 N-(6-phenylpyridin-3-yl)-4-sulfamoylbenzamide 
• 1332586-74-9 4-cyano-N-(6-phenylpyridin-3-yl)benzamide 
• 1357166-19-8 2-(5-nitropyridine-2-yl)phenol 
• 1357165-44-6 C₁₁H₈N₃⁽¹⁺⁾*Cl^(1-) 
• 1357164-10-3 4-amino-3-(6-phenylpyridine-3-ylazo)naphthalene-1-sulfonic acid sodium salt 
• 1344663-50-8 2-phenyl-5-nitropyridine N-oxide 
• 1344663-92-8 2-cyclohexyl-3-nitro-6-phenylpyridine-1-oxide 
• 1344663-91-7 3-nitro-2-isopropyl-6-phenylpyridine-1-oxide 
• 1344663-90-6 3-nitro-6-phenyl-2-p-tolylpyridine-1-oxide 
• 1335110-50-3 5-nitro-2,4-diphenylpyridine 
• 126370-67-0 6-phenylpyridin-3-amine 
• 849353-27-1 (6-phenylpyridin-3-yl)carbamic acid ter-butyl ester 

Relevant articles and documents

Suzuki-Miyaura Cross-Couplings under Acidic Conditions

Suzuki-Miyaura reactions with Pd(PPh 3) 4 have been carried out using lithium N -phenylsydnone-4-carboxylate as additive, which gave best yields at pH 5.7 in a mixture of acetic acid, water, and sodium carbonate. Reaction parameters such as the Pd source, the solvent, reaction time and temperature, acid, base and carboxylate have been varied and some representative examples of the Suzuki-Miyaura reaction have been examined.

Transition-Metal-Free Decarboxylative Arylation of 2-Picolinic Acids with Arenes under Air Conditions

A facile, transition-metal-free, and direct decarboxylative arylation of 2-picolinic acids with simple arenes is described. The oxidative decarboxylative arylation of 2-picolinic acids with arenes proceeds readily via N-chloro carbene intermediates to afford 2-arylpyridines in satisfactory to good yields under transition-metal-free conditions. This new type of decarboxylative arylation is operationally simple and scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, methoxycarbonyl, and nitro, remain intact during the decarboxylative arylation of 2-picolinic acids.

Synthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine

The synthesis, characterization, and a study of the cycloaddition reactions of 5-nitro-1,2,3-triazine (3) are reported. The electron-deficient nature of 3 permits rapid cycloaddition with a variety of electron-rich dienophiles, including amidines, enamines, enol ethers, ynamines, and ketene acetals in high to moderate yields. 1H NMR studies of a representative cycloaddition reaction between 3 and an amidine revealed a remarkable reaction rate and efficiency (1 mM, 3CN, 23 °C, >95%).