4-(2-Chlorophenoxy)piperidine hydrochloride

Base Information

• Chemical Name: 4-(2-Chlorophenoxy)piperidine hydrochloride
• CAS No.: 849107-20-6
• Molecular Formula: C₁₁H₁₄ClNO*ClH
• Molecular Weight: 248.152
• Hs Code.: 2933399090
• European Community (EC) Number: 677-044-8
• DSSTox Substance ID: DTXSID20587449
• Mol file: 849107-20-6.mol

Synonyms:4-(2-Chlorophenoxy)piperidine hydrochloride;849107-20-6;4-(2-CHLOROPHENOXY)PIPERIDINE HCL;4-(2-chlorophenoxy)piperidinehydrochloride;4-(2-chlorophenoxy)piperidine;hydrochloride;4-(2-Chlorophenoxy)piperidine, HCl;MFCD02684107;C11H15Cl2NO;4-(2-Chlorophenoxy)piperidinium chloride;Piperidine,4-(2-chlorophenoxy)-,hydrochloride;SCHEMBL69459;DTXSID20587449;OWOPJLHKPATCOS-UHFFFAOYSA-N;CS-M3134;AR1790;AKOS005111169;AM84964;MCULE-2855604329;SB43129;AS-45208;SY143703;DB-076167;4-(2-chlorophenoxy)-piperidine hydrochloride;4-(2-Chloro-phenoxy)-piperidine hydrochloride;EN300-117292;4-(2-Chlorophenoxy)piperidine hydrochloride, AldrichCPR;4-(2-Chlorophenoxy)piperidine--hydrogen chloride (1/1);Z1511514392

Chemical Property of 4-(2-Chlorophenoxy)piperidine hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 3.60160
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 247.0530695
• Heavy Atom Count: 15
• Complexity: 171

Purity/Quality:

98%min ^*data from raw suppliers

4-(2-Chlorophenoxy)piperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1OC2=CC=CC=C2Cl.Cl

Technology Process of 4-(2-Chlorophenoxy)piperidine hydrochloride

There total 5 articles about 4-(2-Chlorophenoxy)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

4-(2-chloro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (552868-10-7) → 4-(2-chloro-phenoxy)-piperidine hydrochloride (849107-20-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 69.0%

1-benzyl-4-(2-chloro-phenoxy)piperidine (900512-07-4) → 4-(2-chloro-phenoxy)-piperidine hydrochloride (849107-20-6)

Guidance literature:

1-benzyl-4-(2-chloro-phenoxy)piperidine; With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; In dichloromethane; at 0 - 20 ℃; for 0.75h;

With methanol; for 0.5h; Heating / reflux;

Reference yield: 44.0%

→ 4-(2-chloro-phenoxy)-piperidine hydrochloride (849107-20-6)

Guidance literature:

upstream raw materials:

4-(2-chloro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester

2-monochlorophenol

t-butyl 4-hydroxy piperidine-1-carboxylate

1-benzyl-4-(2-chloro-phenoxy)piperidine

Downstream raw materials:

C₂₀H₂₂ClN₃O₄

C₁₉H₂₁ClN₄O₄

Refernces

• 1、 -. "NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS". Paragraph 0214; 0215. . Retrieved 2013/03/26.
• 2、 -. "NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE". Page/Page column 23. . Retrieved 2009/10/01.