(2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester

Base Information

• Chemical Name: (2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester
• CAS No.: 130829-05-9
• Molecular Formula: C₂₁H₂₆Cl₂NO₃P
• Molecular Weight: 442.322
• Mol file: 130829-05-9.mol

Synonyms:(2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester

Chemical Property of (2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester

There total 2 articles about (2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichlorotoluene (32768-54-0) → (2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester (130829-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS / AIBN / CCl₄

2: 1) LDA / 1) THF, - 75 deg C, 1 h, 2) overnight, r.t.

With N-Bromosuccinimide; lithium diisopropyl amide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane;

Reference yield:

O,O-diisopropylbenzylideneaminomethanephosphonate (86423-41-8) + 1-(bromomethyl)-2,3-dichlorobenzene (57915-78-3) → (2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester (130829-05-9)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1) THF, - 75 deg C, 1 h, 2) overnight, r.t.;

Reference yield: 90.4%

(2-(2,3-Dichloro-phenyl)-1-{[1-phenyl-meth-(E)-ylidene]-amino}-ethyl)-phosphonic acid diisopropyl ester (130829-05-9) → [1-Amino-2-(2,3-dichloro-phenyl)-ethyl]-phosphonic acid diisopropyl ester (130882-60-9)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In isopropyl alcohol; at 20 - 25 ℃; for 19h;

upstream raw materials:

O,O-diisopropylbenzylideneaminomethanephosphonate

1-(bromomethyl)-2,3-dichlorobenzene

2,3-dichlorotoluene

Downstream raw materials:

[1-Amino-2-(2,3-dichloro-phenyl)-ethyl]-phosphonic acid diisopropyl ester