1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

Base Information

Chemical Name:1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt
CAS No.:1266350-14-4
Molecular Formula:C₂₆H₃₂N₂O₅*ClH
Molecular Weight:489.011
Hs Code.:

1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

Synonyms:1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

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Chemical Property of 1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

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Technology Process of 1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

There total 5 articles about 1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1266350-13-3
1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carbonitrile hydrochloride salt

: 1266350-14-4
1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

Guidance literature:: With hydrogenchloride; at 20 ℃; for 24h;

Reference yield:

: 532-24-1
tropinone

: 1266350-14-4
1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / toluene; water / 2 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; hexane / 1.75 h / 20 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 2.5 h / 20 °C

4.1: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: hydrogenchloride / 24 h / 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; sodium hydride; potassium carbonate; acetic acid; In methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: Strecker Synthesis;

Reference yield:

: 952423-57-3
benzyl 3-formyl-8-azabicyclo[3.2.1]octane-8-carboxylate

: 1266350-14-4
1-(2-hydroxy-1-(1R)-phenylethyl amino)-1-(8-(benzyloxy carbonyl)-8-aza-bicyclo[3.2.1]-oct-3-yl)-exo-methane-1-(1S)-carboxylic acid methyl ester hydrochloride salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 24 h / 20 °C

With hydrogenchloride; acetic acid; In methanol; 1.1: Strecker Synthesis;