60073-37-2Relevant academic research and scientific papers
4 α-acyloxy -2 the [...] (2 the [...], the 6 [...] ), 2 α-halogenated podophyllotoxin derivatives, and their preparation and use
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Paragraph 0092-0095, (2017/02/28)
The invention discloses a series of new 4alpha-acyloxy-2'(2',6'),2alpha-polyhalogenated podophyllotoxin derivatives and a preparation method thereof. The chemical general formula of the series of 4alpha-acyloxy-2'(2',6'),2alpha-polyhalogenated podophyllot
Synthesis and biological activity of bromolignans and cyclolignans
San Feliciano,Medarde,Pelaez Lamamie De Clairac,Lopez,Puebla,Gravalos,Lazaro,De Quesada
, p. 421 - 426 (2007/10/02)
Nine lignan derivatives (4-12) have been obtained from (-)-yatein by treatment with DDQ and NBS. They showed moderate antineoplastic activity (P-388, A-549, HT-29) compared with podophyllotoxin, but some of them have a better therapeutic index. None of the tested compounds shows antiviral (HSV-1, VSV) or enzyme inhibitor (ADA, DHFR, GST) activities.
