N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

Base Information

Chemical Name:N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide
CAS No.:1254981-29-7
Molecular Formula:C₁₈H₁₈F₃N₃O₂
Molecular Weight:365.355
Hs Code.:

Synonyms:N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

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Chemical Property of N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

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Technology Process of N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

There total 7 articles about N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 54322-65-5
cyclopropylacetyl chloride

: 1254981-28-6
4-(benzyloxy)-2-hydrazineyl-3-(trifluoromethyl)pyridine

: 1254981-29-7
N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1254981-29-7
N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: copper(l) iodide; 2,2-difluoro-2-(fluorosulfonyl)acetate / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed tube

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.03 h / 0 °C

3.2: 0 - 20 °C

4.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

5.1: triethylamine / dichloromethane / 0.33 h / 0 °C

With copper(l) iodide; n-butyllithium; 2,2-difluoro-2-(fluorosulfonyl)acetate; sodium hydride; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 343781-36-2
2,4-dichloro-3-iodo-pyridine

: 1254981-29-7
N'-[4-(benzyloxy)-3-(trifluoromethyl)pyridin-2-yl]-2-cyclopropylacetohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; 2,2-difluoro-2-(fluorosulfonyl)acetate / N,N-dimethyl-formamide / 5 h / 100 °C / Sealed tube

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.03 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrazine hydrate / 1,4-dioxane / 0.5 h / 160 °C / Microwave irradiation

4.1: triethylamine / dichloromethane / 0.33 h / 0 °C

With copper(l) iodide; 2,2-difluoro-2-(fluorosulfonyl)acetate; sodium hydride; hydrazine hydrate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; mineral oil;