2-BROMO-THIAZOLE-5-CARBOXAMIDE

Base Information

• Chemical Name: 2-BROMO-THIAZOLE-5-CARBOXAMIDE
• CAS No.: 848499-31-0
• Molecular Formula: C4H3 Br N2 O S
• Molecular Weight: 207.05
• Hs Code.: 2934100090
• Mol file: 848499-31-0.mol

Synonyms:2-Bromo-1,3-thiazole-5-carboxamide

Chemical Property of 2-BROMO-THIAZOLE-5-CARBOXAMIDE

Chemical Property:

• Boiling Point: 390.7±15.0 °C(Predicted)
• PKA: 14.38±0.50(Predicted)
• PSA: 84.22000
• Density: 1.934±0.06 g/cm3(Predicted)
• LogP: 1.70480
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromothiazole-5-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-bromothiazole-5-carboxamide is a useful reactant for the preparation of thiazole analogs as potent stearoyl-CoA desaturase inhibitors.

Technology Process of 2-BROMO-THIAZOLE-5-CARBOXAMIDE

There total 3 articles about 2-BROMO-THIAZOLE-5-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-bromo-1,3-thiazole-5-carboxylate (41731-83-3) → 2-bromothiazole-5-carboxamide (848499-31-0)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;

Reference yield:

2-bromo-thiazole-5-carboxylic acid (54045-76-0) → 2-bromothiazole-5-carboxamide (848499-31-0)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h;

Reference yield:

→ 2-bromothiazole-5-carboxamide (848499-31-0)

Guidance literature:

upstream raw materials:

ethyl 2-bromo-1,3-thiazole-5-carboxylate

2-bromo-thiazole-5-carboxylic acid

Downstream raw materials:

2-bromothiazole-5-carbonitrile

2-[3-(2-chloro-5-iodophenoxy)propoxy]-1,3-thiazole-5-carboxamide

Refernces

• 1、 -. "NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE". Page/Page column 47; 50. . Retrieved 2011/02/24.
• 2、 -. "HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE". Page/Page column 67-68. . Retrieved 2010/09/17.