Carbamic acid, N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester
• CAS No.: 848472-44-6
• Molecular Formula: C9H14 N2 O2 S
• Molecular Weight: 214.288
• Hs Code.: 2934100090
• Mol file: 848472-44-6.mol

Synonyms:Carbamicacid, (4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI); 1,1-Dimethylethyl(4-methyl-1,3-thiazol-2-yl)carbamate; 4-Methylthiazol-2-ylcarbamic acidtert-butyl ester; tert-Butyl (4-methyl-1,3-thiazol-2-yl)carbamate

Chemical Property of Carbamic acid, N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester

Chemical Property:

• PKA: 5.25±0.70(Predicted)
• PSA: 82.95000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 2.81210

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-butyl4-methylthiazol-2-ylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, N-(4-methyl-2-thiazolyl)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-methylthiazol-2-ylamine (1603-91-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-methylthiazol-2-yl)carbamate (848472-44-6)

Guidance literature:

In tert-butyl alcohol; Product distribution / selectivity;

Reference yield: 76.9%

tert-butyl (4-methylthiazol-2-yl)carbamate (848472-44-6) + 3-Fluorobenzaldehyde (456-48-4) → tert-butyl 5-((3-fluorophenyl)(hydroxy)methyl)-4-methylthiazol-2-ylcarbamate

Guidance literature:

tert-butyl (4-methylthiazol-2-yl)carbamate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

3-Fluorobenzaldehyde; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield: 22.0%

tert-butyl (4-methylthiazol-2-yl)carbamate (848472-44-6) + benzaldehyde (100-52-7) → tert-butyl-{5-[hydroxy(phenyl)methyl]-4-methylthiazol-2-yl}carbamate

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2014.12.006

upstream raw materials:

4-methylthiazol-2-ylamine

di-tert-butyl dicarbonate

Refernces

• 1、 -. "COMPOUNDS AND USES THEREOF". Page/Page column 342. . Retrieved 2020/10/20.
• 2、 -. "COMPOUNDS AND USES THEREOF". Page/Page column 335. . Retrieved 2019/10/15.