(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Base Information

Chemical Name:(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile
CAS No.:1613334-48-7
Molecular Formula:C₂₃H₁₃BrF₃N₃
Molecular Weight:468.276
Hs Code.:

Synonyms:(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Suppliers and Price of (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

There total 3 articles about (Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 929804-33-1
3-formyl-4-(4-trifluorophenyl)benzonitrile

: 1419874-03-5
tert-butyl 5-bromo-3-(cyanomethyl)-1H-indole-1-carboxylate

: 1613334-48-7
(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Guidance literature:: tert-butyl 5-bromo-3-(cyanomethyl)-1H-indole-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h; Inert atmosphere; Darkness;

3-formyl-4-(4-trifluorophenyl)benzonitrile; In tetrahydrofuran; mineral oil; at 20 ℃; for 16h;

Reference yield:

: 774-14-1
(5-bromo-1H-indol-3-yl)-acetonitrile

: 1613334-48-7
(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 1 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Darkness

2.2: 16 h / 20 °C

With dmap; sodium hydride; In tetrahydrofuran; acetonitrile; mineral oil; 2.2: |Knoevenagel Condensation;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 114077-82-6
4-chloronicotinaldehyde

: 1613334-48-7
(Z)-2-(5-bromo-1H-indol-3-yl)-3-(4-(4-(trifluoromethyl)phenyl)pyridin-3-yl)acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 18 h / 85 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Darkness

2.2: 16 h / 20 °C

With palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil; 2.2: |Knoevenagel Condensation;