1-Cbz-Pyrrolidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-Cbz-Pyrrolidine-3-carboxylic acid ethyl ester
• CAS No.: 848413-99-0
• Molecular Formula: C15H19NO4
• Molecular Weight: 277.32
• Hs Code.: 2933990090
• Mol file: 848413-99-0.mol

Synonyms:1-O-benzyl 3-O-ethyl pyrrolidine-1,3-dicarboxylate;3-ethyl 1-phenyl pyrrolidine-1,3-dicarboxylate;

Chemical Property of 1-Cbz-Pyrrolidine-3-carboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 388.5±42.0 °C(Predicted)
• PKA: -2.62±0.40(Predicted)
• PSA: 55.84000
• Density: 1.194±0.06 g/cm3(Predicted)
• LogP: 2.14610

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl3-ethylpyrrolidine-1,3-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Cbz-Pyrrolidine-3-Carboxylic Acid Ethyl Ester can be used as antibacterial agents.

Technology Process of 1-Cbz-Pyrrolidine-3-carboxylic acid ethyl ester

There total 1 articles about 1-Cbz-Pyrrolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-benzyl-3-carboethoxypyrrolidine (5747-92-2) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonylpyrrolidine-3-carboxylic acid ethyl ester (848413-99-0,1263078-10-9)

Guidance literature:

In chloroform;

DOI:10.1016/j.bmcl.2007.01.090

Reference yield: 56.0%

N-benzyloxycarbonylpyrrolidine-3-carboxylic acid ethyl ester (848413-99-0,1263078-10-9) → benzyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate (315718-05-9)

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1016/j.bmcl.2007.01.090

Reference yield:

N-benzyloxycarbonylpyrrolidine-3-carboxylic acid ethyl ester (848413-99-0,1263078-10-9) → C20H27N3O4 (937251-28-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 56 percent / NaBH₄

2: 78 percent / TEMPO; NaOCl

3: 74 percent / Cs₂CO₃

4: NH₃ / ethanol / 80 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium tetrahydroborate; ammonia; caesium carbonate; In ethanol; 3: Horner-Emmons-Wadsworth reaction;

DOI:10.1016/j.bmcl.2007.01.090

upstream raw materials:

1-benzyl-3-carboethoxypyrrolidine

benzyl chloroformate

Downstream raw materials:

benzyl 3-(hydroxymethyl)pyrrolidine-1-carboxylate

C₂₀H₂₇N₃O₄

C₂₁H₂₉N₃O₄

C₂₁H₂₉N₃O₄