4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)-

Base Information

Chemical Name:4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)-
CAS No.:848027-65-6
Molecular Formula:C₁₁H₁₀F₃N₃O₂
Molecular Weight:273.215
Hs Code.:
Mol file:848027-65-6.mol

Synonyms:4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)-

Suppliers and Price of 4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)-

Chemical Property:

PSA：70.14000
LogP:2.15250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)-

There total 4 articles about 4(3H)-Quinazolinone, 3-amino-2-ethyl-8-(trifluoromethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 848027-64-5
2-amino-3-trifluoromethoxybenzoic acid hydrogen chloride

: 79-03-8
propionyl chloride

: 302-01-2,78206-91-4,119775-10-9,75013-58-0
hydrazine

: 848027-65-6
3-Amino-2-ethyl-8-trifluoromethoxy-3H-quinazolin-4-one

Guidance literature:: 2-amino-3-trifluoromethoxybenzoic acid hydrogen chloride; propionyl chloride; With pyridine; In tetrahydrofuran; for 15h; Heating / reflux;

hydrazine; In tetrahydrofuran; at 0 ℃; for 3h; Heating / reflux;

Reference yield:

: 149125-30-4
7-(trifluoromethoxy)indoline-2,3-dione

: 848027-65-6
3-Amino-2-ethyl-8-trifluoromethoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; dihydrogen peroxide / water / 1 h / 80 °C

1.2: 20 °C

2.1: pyridine / tetrahydrofuran / 15 h / Heating / reflux

2.2: 3 h / 0 °C / Heating / reflux

With pyridine; sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water;

Reference yield:

: 848027-63-4
2-(hydroxyimino)-N-(2-(trifluoromethoxy)phenyl)acetamide

: 848027-65-6
3-Amino-2-ethyl-8-trifluoromethoxy-3H-quinazolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 1.5 h / 65 - 80 °C

1.2: 0 °C

2.1: sodium hydroxide; dihydrogen peroxide / water / 1 h / 80 °C

2.2: 20 °C

3.1: pyridine / tetrahydrofuran / 15 h / Heating / reflux

3.2: 3 h / 0 °C / Heating / reflux

With pyridine; sodium hydroxide; sulfuric acid; dihydrogen peroxide; In tetrahydrofuran; water;