6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

Base Information

Chemical Name:6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile
CAS No.:405111-40-2
Molecular Formula:C₂₁H₁₅N₅O
Molecular Weight:353.383
Hs Code.:

Synonyms:6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

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Technology Process of 6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

There total 3 articles about 6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 141-97-9
ethyl acetoacetate

: 100-63-0
phenylhydrazine

: 105-07-7
4-cyanobenzaldehyde

: 109-77-3
malononitrile

: 405111-40-2
6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

Guidance literature:: With super-paramagnetic Fe₃O₄ nanoparticles-supported dopamine-bridged L-proline; In water; at 20 ℃; for 0.05h; Sonication; Green chemistry;
DOI:10.1007/s10562-015-1586-4

Reference yield: 96.0%

: 105-07-7
4-cyanobenzaldehyde

: 89-25-8
edaravone

: 109-77-3
malononitrile

: 405111-40-2
6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

Guidance literature:: With C₉H₁₈N₂O₃PolSi⁽¹⁺⁾*Cl^(1-); In ethanol; at 20 ℃; for 0.416667h;
DOI:10.1016/j.apcata.2011.04.012

Reference yield:

: 100-63-0
phenylhydrazine

: 405111-40-2
6-amino-4-(4-cyanophenyl)-1,4-dihydro-3-methyl-1-phenylpyrano[2,3-c]pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfonic acid immobilized on 3-chloropropyltrimethoxy silane-modified silica-coated Fe₃O₄ magnetic nanoparticles decorated on the surface of nanobentonite / 0.83 h / 50 °C

2.1: sulfonic acid immobilized on 3-chloropropyltrimethoxy silane-modified silica-coated Fe₃O₄ magnetic nanoparticles decorated on the surface of nanobentonite / water; ethanol / 0.5 h / 20 °C / Green chemistry

2.2: 0.67 h / Reflux; Green chemistry

With sulfonic acid immobilized on 3-chloropropyltrimethoxy silane-modified silica-coated Fe₃O₄ magnetic nanoparticles decorated on the surface of nanobentonite; In ethanol; water;
DOI:10.1002/aoc.5406