(S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

Base Information

Chemical Name:(S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate
CAS No.:1403506-10-4
Molecular Formula:C₂₂H₂₂ClN₃O₈S
Molecular Weight:523.951
Hs Code.:

Synonyms:(S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

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Chemical Property of (S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

Chemical Property:

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Technology Process of (S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

There total 8 articles about (S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 661470-52-6,167273-56-5,661470-53-7
(S)-2-(phenoxymethyl)morpholine

: 1403879-02-6
C₁₁H₈Cl₂N₂O₆S

: 1403506-10-4
(S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; for 4h;

Reference yield:

: 89-63-4
4-Chloro-2-nitroaniline

: 1403506-10-4
(S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 0 - 10 °C / Industry scale

1.2: 0.5 h / -5 - 0 °C

2.1: Polyphosphoric acid (PPA) / 110 °C

3.1: acetic anhydride; sulfuric acid / 0 - 20 °C

3.2: 0 - 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 10 °C

5.1: triethylamine / dichloromethane / 4 h

With oxalyl dichloride; sulfuric acid; acetic anhydride; triethylamine; potassium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; water;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1403506-10-4
(S)-ethyl 5-chloro-7-nitro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / water / 1 h / 20 - 100 °C

2.1: sodium hydroxide / water / 0.17 h / 10 - 20 °C

2.2: 15 h / 45 - 50 °C

3.1: ammonium formate / palladium 10% on activated carbon / 1 h / 20 °C / Reflux; Cooling with dry ice

4.1: triethylamine / dichloromethane / 4 h

With ammonium formate; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In dichloromethane; water;