(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

Base Information

Chemical Name:(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal
CAS No.:331414-51-8
Molecular Formula:C₂₇H₃₄O₄
Molecular Weight:422.565
Hs Code.:

Synonyms:(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

Suppliers and Price of (2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

There total 11 articles about (2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 331414-50-7
(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-en-1-ol

: 331414-51-8
(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ja005892h

Reference yield:

: 331414-49-4
(4R)-4-benzyl-3-[(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enoyl]-oxazolidin-2-one

: 331414-51-8
(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaBH₄; H₂O / tetrahydrofuran / 5 - 20 °C

2: (COCl)2; DMSO / CH₂Cl₂ / 0.42 h / -78 °C

With sodium tetrahydroborate; oxalyl dichloride; water; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1016/S0040-4020(02)00040-6

Reference yield:

: 289619-01-8
(4R)-4-benzyl-3-[2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-acetyl]-oxazolidin-2-one

: 331414-51-8
(2S,4E)-6-benzyloxy-2-((1R,2R)-2-benzyloxy-1-ethyl-pent-4-enyloxy)-hex-4-enal

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaN(SiMe₃)2 / toluene; tetrahydrofuran / 0.5 h / -78 °C

1.2: 75 percent / toluene; tetrahydrofuran / 2 h / -45 °C

2.1: 88 percent / NaBH₄; H₂O / tetrahydrofuran / 5 - 20 °C

3.1: (COCl)2; DMSO / CH₂Cl₂ / 0.42 h / -78 °C

With sodium tetrahydroborate; oxalyl dichloride; water; sodium hexamethyldisilazane; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; toluene; 3.1: Swern oxidation;
DOI:10.1016/S0040-4020(02)00040-6