(E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one
CAS No.:1632147-75-1
Molecular Formula:C₂₄H₁₆F₆O₂
Molecular Weight:450.38
Hs Code.:

Synonyms:(E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

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Chemical Property of (E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

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Technology Process of (E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

There total 4 articles about (E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 5720-07-0
4-methoxyphenylboronic acid

: 119757-51-6
1,2-bis(4-(trifluoromethyl)phenyl)ethyne

: 1632147-76-2
(Z)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 1632147-75-1
(E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Guidance literature:: With chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis(diphenylphosphino)biphenyl; In 1,4-dioxane; at 80 ℃; for 20h; Overall yield = 54 %; Inert atmosphere; Sealed tube;
DOI:10.1055/s-0033-1341046

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 1632147-76-2
(Z)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 1632147-75-1
(E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diethylamine / Inert atmosphere; Reflux

4.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis(diphenylphosphino)biphenyl / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 2,2'-bis(diphenylphosphino)biphenyl; diethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 3.1: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0033-1341046

Reference yield:

: 131356-53-1
1-(2,2-dibromovinyl)-4-(trifluoromethyl)benzeney

: 1632147-76-2
(Z)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

: 1632147-75-1
(E)-1-(4-methoxyphenyl)-2,3-bis(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; diethylamine / Inert atmosphere; Reflux

3.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; 2,2'-bis(diphenylphosphino)biphenyl / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere; Sealed tube

With copper(l) iodide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; 2,2'-bis(diphenylphosphino)biphenyl; diethylamine; In tetrahydrofuran; 1,4-dioxane; 2.1: |Sonogashira Cross-Coupling;
DOI:10.1055/s-0033-1341046