methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

Base Information

Chemical Name:methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate
CAS No.:1374298-76-6
Molecular Formula:C₂₀H₁₇ClFN₃O₄
Molecular Weight:417.824
Hs Code.:

Synonyms:methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

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Chemical Property of methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

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Technology Process of methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

There total 11 articles about methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374298-77-7
methyl 2-amino-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

: 434-75-3
2-chloro-6-fluorobenzoic acid

: 1374298-76-6
methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; for 18h;

Reference yield:

: 1583-58-0
2,4-difluoro-benzoic acid

: 1374298-76-6
methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: sulfuric acid; nitric acid / water / 14 h / 0 - 5 °C

2.1: sulfuric acid / ethanol / 24 h / Reflux

3.1: triethylamine / tetrahydrofuran / 0 - 26 °C

4.1: sodium methylate / methanol; water / 0 - 26 °C

5.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

6.2: 80 °C

7.1: N,N-diethylaniline / 1.3 h / Reflux

8.1: formic acid / 100 °C

9.1: hydrogenchloride; iron / methanol; water / 1 h / 22 - 26 °C

10.1: ethanol; water / Reflux

11.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 18 h

With hydrogenchloride; aluminum (III) chloride; formic acid; sulfuric acid; nitric acid; sodium methylate; iron; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-diethylaniline; sulfuric acid; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 1374298-76-6
methyl 2-(2-chloro-6-fluorobenzamido)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / ethanol / 24 h / Reflux

2.1: triethylamine / tetrahydrofuran / 0 - 26 °C

3.1: sodium methylate / methanol; water / 0 - 26 °C

4.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

5.2: 80 °C

6.1: N,N-diethylaniline / 1.3 h / Reflux

7.1: formic acid / 100 °C

8.1: hydrogenchloride; iron / methanol; water / 1 h / 22 - 26 °C

9.1: ethanol; water / Reflux

10.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 18 h

With hydrogenchloride; aluminum (III) chloride; formic acid; sodium methylate; iron; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-diethylaniline; sulfuric acid; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;