Technology Process of (3aR,5R,6S,6aR)-6-(2-Allyloxy-benzyloxy)-2,2-dimethyl-5-(2-nitro-ethyl)-tetrahydro-furo[2,3-d][1,3]dioxole
There total 5 articles about (3aR,5R,6S,6aR)-6-(2-Allyloxy-benzyloxy)-2,2-dimethyl-5-(2-nitro-ethyl)-tetrahydro-furo[2,3-d][1,3]dioxole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
nitromethane; (3aR,5S,6S,6aR)-6-(2-Allyloxy-benzyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole-5-carbaldehyde;
With
potassium fluoride;
In
isopropyl alcohol;
at 25 ℃;
for 24h;
acetic anhydride;
With
dmap;
In
diethyl ether; dichloromethane;
at 25 ℃;
for 12h;
With
sodium tetrahydroborate;
In
tetrahydrofuran; ethanol;
at 0 ℃;
for 4h;
DOI:10.1016/S0040-4020(00)00844-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 78 percent / Bu4NBr / CH2Cl2; aq. NaOH / 4 h / 25 °C
2.1: 83 percent / aq. AcOH / 14 h / 20 °C
3.1: NaIO4 / methanol; H2O / 1.5 h / 0 - 25 °C
4.1: KF / propan-2-ol / 24 h / 25 °C
4.2: DMAP / diethyl ether; CH2Cl2 / 12 h / 25 °C
4.3: 77 percent / NaBH4 / ethanol; tetrahydrofuran / 4 h / 0 °C
With
potassium fluoride; sodium periodate; tetrabutylammomium bromide; acetic acid;
In
methanol; sodium hydroxide; dichloromethane; water; isopropyl alcohol;
1.1: Alkylation / 2.1: Hydrolysis / 3.1: Oxidative cleavage / 4.1: Condensation / 4.2: Acetylation / 4.3: Reduction;
DOI:10.1016/S0040-4020(00)00844-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 78 percent / Bu4NBr / CH2Cl2; aq. NaOH / 4 h / 25 °C
2.1: 83 percent / aq. AcOH / 14 h / 20 °C
3.1: NaIO4 / methanol; H2O / 1.5 h / 0 - 25 °C
4.1: KF / propan-2-ol / 24 h / 25 °C
4.2: DMAP / diethyl ether; CH2Cl2 / 12 h / 25 °C
4.3: 77 percent / NaBH4 / ethanol; tetrahydrofuran / 4 h / 0 °C
With
potassium fluoride; sodium periodate; tetrabutylammomium bromide; acetic acid;
In
methanol; sodium hydroxide; dichloromethane; water; isopropyl alcohol;
1.1: Alkylation / 2.1: Hydrolysis / 3.1: Oxidative cleavage / 4.1: Condensation / 4.2: Acetylation / 4.3: Reduction;
DOI:10.1016/S0040-4020(00)00844-9
