6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI)

Base Information

Chemical Name:6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI)
CAS No.:827609-16-5
Molecular Formula:C₇H₆O₂S
Molecular Weight:154.189
Hs Code.:
Mol file:827609-16-5.mol

Synonyms:6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI)

Suppliers and Price of 6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI)

Chemical Property:

PSA：65.54000
LogP:0.84780

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI)

There total 5 articles about 6H-Cyclopenta[b]thiophen-6-one,4,5-dihydro-5-hydroxy-,(5R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 827609-11-0
(5R,2S)-6-oxo-5,6-dihydro-4H-cyclopenta[b]thien-5-yl 2-[(tert-butoxycarbonyl)amino]-3-phenylpropanoate

: 827609-16-5,827609-18-7
(R)-5-hydroxy-4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

Guidance literature:: With hydrogenchloride; In methanol; at 30 ℃; for 20h;
DOI:10.1002/ejoc.200400351

Reference yield:

: 16378-06-6
3-(3-thienyl)propanoic acid

: 827609-16-5,827609-18-7
(R)-5-hydroxy-4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 54 percent / phosphorus pentoxide; methanesulfonic acid / 0.67 h / 20 °C

2.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C

2.2: 70 percent / HCl / ethanol / 4 h / 20 °C

3.1: 1.35 g / dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 8 h / 20 °C

4.1: 80 percent / HCl / methanol / 20 h / 30 °C

With hydrogenchloride; dmap; phosphorus pentaoxide; potassium hydroxide; methanesulfonic acid; [bis(acetoxy)iodo]benzene; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1002/ejoc.200400351

Reference yield:

: 5650-52-2
4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

: 827609-16-5,827609-18-7
(R)-5-hydroxy-4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: KOH; iodobenzene diacetate / methanol / 24 h / 20 °C

1.2: 70 percent / HCl / ethanol / 4 h / 20 °C

2.1: 1.35 g / dicyclohexylcarbodiimide; DMAP / CH₂Cl₂ / 8 h / 20 °C

3.1: 80 percent / HCl / methanol / 20 h / 30 °C

With hydrogenchloride; dmap; potassium hydroxide; [bis(acetoxy)iodo]benzene; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1002/ejoc.200400351