2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester
CAS No.:627461-49-8
Molecular Formula:C₆₂H₁₀₀O₁₃Si₂
Molecular Weight:1109.64
Hs Code.:

2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

Synonyms:2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

There total 11 articles about 2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 287400-80-0
[2S,3R]-2-methyl-3-[(triethylsilyl)oxy]-6-trimethylacetoxy-heptanal

: 287400-71-9
(S)-1-[(2R,3R,4R,5S,6R)-4,5-Bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-1-(4-methoxy-benzyloxy)-propan-2-one

: 627461-49-8
2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/jo0002801

Reference yield:

: 994-30-9
triethylsilyl chloride

: 627461-49-8
2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / imidazole / dimethylformamide / 0.33 h / 0 °C

2: 92 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

3: 94 percent / Et₃SiH / Pd/C / CH₂Cl₂ / 0.25 h

4: 88 percent / LiHMDS / tetrahydrofuran; various solvent(s) / 0.5 h / -78 °C

With 1H-imidazole; triethylsilane; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1: silylation / 2: Substitution / 3: Reduction / 4: Condensation;
DOI:10.1021/jo0002801

Reference yield:

: 287401-05-2
5-oxopentyl-2',2'-dimethylpropanoate

: 627461-49-8
2,2-Dimethyl-propionic acid (5R,6R,10S)-10-[(2R,3R,4R,5S,6R)-4,5-bis-(4-methoxy-benzyloxy)-3-methyl-6-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-7-hydroxy-10-(4-methoxy-benzyloxy)-6-methyl-9-oxo-5-triethylsilanyloxy-decyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Bu₂BOTf; diisopropylethylamine / CH₂Cl₂ / -78 - 0 °C

2: 95 percent / imidazole / dimethylformamide / 0.33 h / 0 °C

3: 92 percent / tetrahydrofuran; hexane / 0.5 h / 0 °C

4: 94 percent / Et₃SiH / Pd/C / CH₂Cl₂ / 0.25 h

5: 88 percent / LiHMDS / tetrahydrofuran; various solvent(s) / 0.5 h / -78 °C

With 1H-imidazole; triethylsilane; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: silylation / 3: Substitution / 4: Reduction / 5: Condensation;
DOI:10.1021/jo0002801