1,3-Dimethyl-2-(2-methoxyphenyl)imidazolidine

Base Information

• Chemical Name: 1,3-Dimethyl-2-(2-methoxyphenyl)imidazolidine
• CAS No.: 124639-28-7
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.288
• European Community (EC) Number: 661-539-0
• Nikkaji Number: J2.948.375B
• Mol file: 124639-28-7.mol

Synonyms:1,3-Dimethyl-2-(2-methoxyphenyl)imidazolidine;124639-28-7;2-(2-methoxyphenyl)-1,3-dimethylimidazolidine;SCHEMBL4009783;DTAJDRLUKOKLPI-UHFFFAOYSA-N;AKOS024339188

Chemical Property of 1,3-Dimethyl-2-(2-methoxyphenyl)imidazolidine

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 206.141913202
• Heavy Atom Count: 15
• Complexity: 200

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCN(C1C2=CC=CC=C2OC)C

Technology Process of 1,3-Dimethyl-2-(2-methoxyphenyl)imidazolidine

There total 1 articles about 1,3-Dimethyl-2-(2-methoxyphenyl)imidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ortho-anisaldehyde (135-02-4) + N,N`-dimethylethylenediamine (110-70-3) → 2-(2-methoxyphenyl)-1,3-dimethylimidazolidine (124639-28-7)

Guidance literature:

In ethanol; at 25 ℃; for 24h; Inert atmosphere;

Reference yield: 52.0%

2-(2-methoxyphenyl)-1,3-dimethylimidazolidine (124639-28-7) → 2-bromo-6-methoxybenzaldehyde (126712-07-0)

Guidance literature:

2-(2-methoxyphenyl)-1,3-dimethylimidazolidine; With tert.-butyl lithium; In diethyl ether; pentane; at -40 - -20 ℃; for 8h; Inert atmosphere;

With 1,2-dibromo-1,1,2,2-tetrachloroethane; In diethyl ether; pentane; at 0 - 25 ℃; for 12h;

With hydrogenchloride; water; In diethyl ether; pentane; at 0 ℃; for 1h;

Reference yield: 46.0%

2-(2-methoxyphenyl)-1,3-dimethylimidazolidine (124639-28-7) → 2-iodo-6-methoxybenzaldehyde (5025-59-2)

Guidance literature:

2-(2-methoxyphenyl)-1,3-dimethylimidazolidine; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - 20 ℃; Inert atmosphere;

With 1,2-Diiodoethane; In diethyl ether; pentane; at -78 - 20 ℃; for 0.5h;

upstream raw materials:

ortho-anisaldehyde

N,N`-dimethylethylenediamine

Downstream raw materials:

2-methoxy-6-methylthiobenzaldehyde

2-methoxy-3-methylthiobenzaldehyde

2-bromo-6-hydroxybenzaldehyde

2-bromo-6-methoxybenzaldehyde

Refernces

• 1、 -. "SYNTHESIS OF THE POTENT IMMUNOSUPPRESSANT AGENTS DALESCONOL A AND B". Page/Page column 72-73. . Retrieved 2011/09/19.
• 2、 Snyder, Scott A.,Sherwood, Trevor C.,Ross, Audrey G.. "Total syntheses of dalesconol A and B". supporting information; experimental part. p. 5146 - 5150. Retrieved 2010/11/04.