2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

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Chemical Name:2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide
CAS No.:946129-85-7
Molecular Formula:C₂₄H₂₁FN₄O₆S
Molecular Weight:512.518
Hs Code.:

Synonyms:2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

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Chemical Property of 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

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Technology Process of 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

There total 13 articles about 2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 946126-93-8
C₂₃H₁₈FN₃O₇S

: 74-89-5
methylamine

: 946129-85-7
2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 19h;

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 946129-85-7
2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: cesium fluoride / dimethyl sulfoxide / 0.67 h / 140 °C

2.1: diisobutylaluminium hydride / toluene / 1 h / -78 - 0 °C

2.2: 1 h / -78 - 20 °C

3.1: phosphorus tribromide / diethyl ether / 0.5 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 20 °C

5.1: sulfuric acid / 0 - 20 °C

6.1: tin(II) chloride hydrate / ethyl acetate / 1 h / Inert atmosphere; Reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

7.2: 5 h / 100 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere

8.2: 1 h / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

With 3-hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazole; tin(II) chloride hydrate; sulfuric acid; phosphorus tribromide; sodium hydride; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium fluoride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 437-86-5
2-fluoro-3-nitrotoluene

: 946129-85-7
2-{2-fluoro-3-[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-1-benzopyran-3-ylmethyl]phenylsulfamoyl}-N-methylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 5 h / Reflux; Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 20 °C

3.1: sulfuric acid / 0 - 20 °C

4.1: tin(II) chloride hydrate / ethyl acetate / 1 h / Inert atmosphere; Reflux

5.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

5.2: 5 h / 100 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere

6.2: 1 h / Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 3-hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazole; tin(II) chloride hydrate; sulfuric acid; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;