methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate

Base Information

• Chemical Name: methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate
• CAS No.: 75156-82-0
• Molecular Formula: C₁₂H₁₄Br₂O₄
• Molecular Weight: 382.049
• Mol file: 75156-82-0.mol

Synonyms:methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate

Chemical Property of methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate

There total 6 articles about methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-4-methylbenzaldehyde (57295-30-4) → methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate (75156-82-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 87 percent / aq. potassium hydroxide (33percent w/w)

2: 98.7 percent / sodium borohydride / methanol

3: 1.) thionyl chloride, 2.) sodium iodide, H₂O / 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h

4: 65 percent / sodum acetate, bromine / CHCl₃ / 1 h / Ambient temperature

5: 98.4 percent / 0.85N methanolic potassium hydroxide, H₂O / 36 h / Heating

6: 1.) thionyl chloride, 2.) N-bromosuccinimide, 30percent hydrogen bromide in acetic acid (10 drops), 3.) conc. sulphuric acid

With potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; sulfuric acid; water; hydrogen bromide; bromine; sodium acetate; sodium iodide; In methanol; chloroform;

DOI:10.1039/P19800001607

Reference yield:

3-methoxy-4-methylbenzaldehyde (24973-22-6) → methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate (75156-82-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 98.7 percent / sodium borohydride / methanol

2: 1.) thionyl chloride, 2.) sodium iodide, H₂O / 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h

3: 65 percent / sodum acetate, bromine / CHCl₃ / 1 h / Ambient temperature

4: 98.4 percent / 0.85N methanolic potassium hydroxide, H₂O / 36 h / Heating

5: 1.) thionyl chloride, 2.) N-bromosuccinimide, 30percent hydrogen bromide in acetic acid (10 drops), 3.) conc. sulphuric acid

With potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; sulfuric acid; water; hydrogen bromide; bromine; sodium acetate; sodium iodide; In methanol; chloroform;

DOI:10.1039/P19800001607

Reference yield:

3-methoxy-4-methylbenzyl alcohol (4685-50-1) → methyl α-bromo-(2-bromo-5-methoxy-4-methoxymethylphenyl)acetate (75156-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) thionyl chloride, 2.) sodium iodide, H₂O / 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h

2: 65 percent / sodum acetate, bromine / CHCl₃ / 1 h / Ambient temperature

3: 98.4 percent / 0.85N methanolic potassium hydroxide, H₂O / 36 h / Heating

4: 1.) thionyl chloride, 2.) N-bromosuccinimide, 30percent hydrogen bromide in acetic acid (10 drops), 3.) conc. sulphuric acid

With potassium hydroxide; N-Bromosuccinimide; thionyl chloride; sulfuric acid; water; hydrogen bromide; bromine; sodium acetate; sodium iodide; In chloroform;

DOI:10.1039/P19800001607

upstream raw materials:

methanol

2-bromo-5-methoxy-4-methylphenylacetic acid

3-hydroxy-4-methylbenzaldehyde

3-methoxy-4-methylbenzaldehyde

Downstream raw materials:

methyl α-<3-acetoxy-4-(N-ethoxycarbonyl-N-methylamino)-pyrrolidin-2-ylidene>-α-(2-bromo-5-methoxy-4-methoxymethylphenyl)-acetate