(S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

Base Information

Chemical Name:(S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide
CAS No.:1383709-59-8
Molecular Formula:C₂₇H₂₉FN₂O₄
Molecular Weight:464.537
Hs Code.:

Synonyms:(S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

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Chemical Property of (S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

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Technology Process of (S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

There total 5 articles about (S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1383709-58-7
(S)-N-(4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

: 77-76-9
2,2-dimethoxy-propane

: 1383709-59-8
(S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

Guidance literature:: With toluene-4-sulfonic acid; at 20 - 60 ℃; for 120h;

Reference yield:

: 116632-24-7
2-amino-4,6-dichloropyridine

: 1383709-59-8
(S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: tetrabutyl ammonium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 72 h / 80 °C / Inert atmosphere

4: isopropyl alcohol; (DHQD)₂Phal / water

5: toluene-4-sulfonic acid / 120 h / 20 - 60 °C

With (DHQD)₂Phal; tetrabutyl ammonium fluoride; sodium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 1383709-54-3
4-chloro-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-amine

: 1383709-59-8
(S)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)-6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)pivalamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: tetrabutyl ammonium fluoride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 72 h / 80 °C / Inert atmosphere

3: isopropyl alcohol; (DHQD)₂Phal / water

4: toluene-4-sulfonic acid / 120 h / 20 - 60 °C

With (DHQD)₂Phal; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water;