but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

Base Information

Chemical Name:but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide
CAS No.:881653-59-4
Molecular Formula:C₃₆H₃₈N₂O₃Si
Molecular Weight:574.795
Hs Code.:

but-2-ynedioic acid benzyl-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

Synonyms:but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

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Chemical Property of but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

Chemical Property:

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Technology Process of but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

There total 5 articles about but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881653-57-2
N-benzyl-2-((tert-butyldimethylsilyl)oxy)aniline

: 881653-55-0
(benzyl-phenyl-carbamoyl)-propynoic acid

: 881653-59-4
but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -60 - -5 ℃;
DOI:10.1021/jo052335a

Reference yield:

: 881653-53-8
propynoic acid benzyl-phenyl-amide

: 881653-59-4
but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: 19.6 g / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / -60 - -5 °C

With n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo052335a

Reference yield:

: 758640-21-0,103-32-2
N-Benzylaniline

: 881653-59-4
but-2-ynedioic acid benzyl-[2-(tert-butyl-dimethyl-silanyloxy)-phenyl]-amide benzyl-phenyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h / -10 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 20 °C

3.1: 19.6 g / 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / -60 - -5 °C

With n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo052335a