350795-08-3

Upstream product

• 105-38-4 vinyl propionate 
• 294198-21-3 4-Cyano-5-methyl-4-phenylhexanol 
• 108-24-7 acetic anhydride 
• 294198-22-4 (+/-)-methyl 4-cyano-5-methyl-4-phenylhexanoate 
• 5558-29-2 3-methyl-2-phenyl-butyronitrile 
• 350795-04-9 (2S,3S)-3-isopropyl-2-phenyl-2,3-epoxypropan-1-triphenylsilyl ether 
• 350795-05-0 (S)-3-methyl-2-phenyl-2-((triphenylsilyloxy)methyl)butanal 
• 350795-07-2 ethyl (4R)-4-cyano-4-phenyl-5-methyl-trans-hex-2-enoate 
• 350795-03-8 (2S,3S)-3-isopropyl-2-phenyl-2,3-epoxypropan-1-ol 
• 350795-06-1 (2R)-2-hydroxymethyl-2-isopropyl-2-phenylacetonitrile 
• 458557-61-4 (R)-2-Formyl-3-methyl-2-phenyl-butyronitrile 
• 318969-12-9 ethyl (4S)-4-cyano-4-phenyl-5-methylhexanoate 
• 352196-07-7 (+/-)-4-cyano-5-methyl-4-phenylhexyl propionate 
• 493006-61-4 (S)-(-)-4-cyano-5-methyl-4-phenylhexyl acetate 

Downstream Products

• 493006-79-4 (S)-4-cyano-5-methyl-4-phenylhexyl mesylate 
• 186763-30-4 (S)-2-isopropyl-5-oxo-2-phenylpentanenitrile 

Relevant academic research and scientific papers

Enantioselective synthesis of (2S)-5-{4-[2-(4-fluorophenoxy)ethyl]piperazin-1-yl}-2-isopropyl-2-phenyl- pentanenitrile dihydrochloride (E2050) using enzyme-catalyzed kinetic resolution

Immobilized lipase (Pseudomonas sp.)-catalyzed transesterification of (RS)-4-cyano-4-isopropyl-4-phenyl-1-butanol 4 in vinyl acetate gave (S)-4-cyano-4-isopropyl-4-phenyl-1-butyl acetate 3a with high enantiomeric excess values and conversions (95-97% ee,

Practical synthesis of chiral emopamil left hand as a bioactive motif.

An asymmetric synthesis of (2S)-2-(2-isopropyl)-5-hydroxy-2-phenylpentanenitrile (emopamil left hand, 2) has been completed by use of the MAD (methyl aluminum bis(4-methyl-2,6-di-tert-butylphenoxide)-induced rearrangement of a chiral epoxyalcohol as the key reaction. The stereochemistry of the chiral quaternary center was confirmed by transformation of 2 to (S)-noremopamil. This method requires minimal purification procedures and affords high chemical and optical yields. Acid-catalyzed isomerization of an allylaldehyde and retro-aldol type racemization at the quaternary carbon of a nitrile-alcohol were encountered.