methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Base Information

Chemical Name:methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate
CAS No.:886041-56-1
Molecular Formula:C₂₉H₃₇N₃O₃
Molecular Weight:475.631
Hs Code.:

Synonyms:methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Suppliers and Price of methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

There total 6 articles about methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886041-55-0
methyl 14-cyclohexyl-7-oxo-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

: 108-00-9
N,N-dimethylethylenediamine

: 886041-56-1
methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: methyl 14-cyclohexyl-7-oxo-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate; N,N-dimethylethylenediamine; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; for 2h;

With sodium hydroxide; water; In dichloromethane;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 886041-56-1
methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

2: cesium fluoride / N,N-dimethyl-formamide / 20 °C

3: caesium carbonate / 1,4-dioxane / 48 h / Reflux

4: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium tris(acetoxy)borohydride; sodium carbonate; caesium carbonate; Dess-Martin periodane; acetic acid; cesium fluoride; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm1013105

Reference yield:

: 863578-50-1
3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester

: 886041-56-1
methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / N,N-dimethyl-formamide / 20 °C

2: caesium carbonate / 1,4-dioxane / 48 h / Reflux

3: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; caesium carbonate; Dess-Martin periodane; acetic acid; cesium fluoride; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1013105