methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Base Information

Chemical Name:methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate
CAS No.:886041-59-4
Molecular Formula:C₃₀H₃₉N₃O₃
Molecular Weight:489.658
Hs Code.:

Synonyms:methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

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Chemical Property of methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

There total 7 articles about methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 886041-56-1
methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

: 886041-59-4
methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: formaldehyd; methyl 14-cyclohexyl-7-{[2-(dimethylamino)ethyl]amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate; With sodium cyanoborohydride; acetic acid; In dichloromethane; for 2h;

With sodium hydroxide; water; In dichloromethane; for 0.0833333h;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 886041-59-4
methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 4 h / 110 °C / Inert atmosphere

2: cesium fluoride / N,N-dimethyl-formamide / 20 °C

3: caesium carbonate / 1,4-dioxane / 48 h / Reflux

4: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

5: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

6: sodium cyanoborohydride; acetic acid / dichloromethane; water / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; sodium carbonate; caesium carbonate; Dess-Martin periodane; acetic acid; cesium fluoride; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm1013105

Reference yield:

: 863578-50-1
3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester

: 886041-59-4
methyl 14-cyclohexyl-7-[[2-(dimethylamino)ethyl](methyl)amino]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: cesium fluoride / N,N-dimethyl-formamide / 20 °C

2: caesium carbonate / 1,4-dioxane / 48 h / Reflux

3: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 2 h / 20 °C

5: sodium cyanoborohydride; acetic acid / dichloromethane; water / 2 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium cyanoborohydride; caesium carbonate; Dess-Martin periodane; acetic acid; cesium fluoride; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm1013105