N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

Base Information

Chemical Name:N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester
CAS No.:1443252-63-8
Molecular Formula:C₂₀H₂₇Cl₃N₄O₃
Molecular Weight:477.818
Hs Code.:

Synonyms:N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

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Chemical Property of N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

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Technology Process of N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

There total 9 articles about N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946050-88-0
5-tert-butyl-2-[3-(2-dimethylaminoethoxy)phenyl]-2H-pyrazol-3-ylamine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1443252-63-8
N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h;

Reference yield:

: 946050-88-0
5-tert-butyl-2-[3-(2-dimethylaminoethoxy)phenyl]-2H-pyrazol-3-ylamine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1443252-63-8
N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

: N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1443252-63-8
N-(3-tert-butyl-1-{3-[2-(dimethylamino)ethoxy]phenyl}-1H-pyrazol-5-yl)carbamic acid 2,2,2-trichloroethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 18 h / 100 °C

2: aluminum (III) chloride / dichloromethane / 36 h / 45 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 72 h

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h

With aluminum (III) chloride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;