Technology Process of [(2R,3S,5S,6R)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-2,6-dimethyl-heptane-1-sulfonyl]-benzene
There total 13 articles about [(2R,3S,5S,6R)-5,7-Bis-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-2,6-dimethyl-heptane-1-sulfonyl]-benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 8.15 g / imidazole / dimethylformamide / 11 h / 50 °C
2.1: 92 percent / H2; NaHCO3 / Pd/C / ethyl acetate / 11 h / 20 °C
3.1: 89 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 0 °C
4.1: dibutylboron triflate; Et3N / CH2Cl2 / 0.67 h / 0 °C
4.2: 100 percent / CH2Cl2 / 2.33 h / -78 - 0 °C
5.1: 100 percent / LiBH4; EtOH / 0.5 h / -10 °C
6.1: 99 percent / tributylphosphine / dimethylformamide / 11 h / 20 °C
7.1: 99 percent / m-chloroperoxybenzoic acid; NaHCO3 / CH2Cl2 / 0.33 h / 0 - 20 °C
8.1: 95 percent / NaH / tetrahydrofuran / 16 h / 20 °C
With
1H-imidazole; lithium borohydride; oxalyl dichloride; ethanol; tributylphosphine; di-n-butylboryl trifluoromethanesulfonate; hydrogen; sodium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.06.046
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: NaBH4; EtOH / 0.33 h / 20 °C
2.1: 8.15 g / imidazole / dimethylformamide / 11 h / 50 °C
3.1: 92 percent / H2; NaHCO3 / Pd/C / ethyl acetate / 11 h / 20 °C
4.1: 89 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / -78 - 0 °C
5.1: dibutylboron triflate; Et3N / CH2Cl2 / 0.67 h / 0 °C
5.2: 100 percent / CH2Cl2 / 2.33 h / -78 - 0 °C
6.1: 100 percent / LiBH4; EtOH / 0.5 h / -10 °C
7.1: 99 percent / tributylphosphine / dimethylformamide / 11 h / 20 °C
8.1: 99 percent / m-chloroperoxybenzoic acid; NaHCO3 / CH2Cl2 / 0.33 h / 0 - 20 °C
9.1: 95 percent / NaH / tetrahydrofuran / 16 h / 20 °C
With
1H-imidazole; sodium tetrahydroborate; lithium borohydride; oxalyl dichloride; ethanol; tributylphosphine; di-n-butylboryl trifluoromethanesulfonate; hydrogen; sodium hydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2006.06.046
