(3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Base Information

Chemical Name:(3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one
CAS No.:1340590-02-4
Molecular Formula:C₂₁H₂₃NO₂
Molecular Weight:321.419
Hs Code.:

Synonyms:(3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

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Chemical Property of (3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

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Technology Process of (3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

There total 4 articles about (3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1061681-25-1
(3R,11aS)-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

: 75-03-6
ethyl iodide

: 1340590-02-4
(3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Guidance literature:: (3R,11aS)-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at -78 ℃; for 3h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.07.027

Reference yield:

: 7500-53-0
1,2-Phenylenediacetic acid

: 1340590-02-4
(3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 24 h / 0 - 20 °C

2.1: toluene / 120 °C / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 °C / Inert atmosphere

With lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetasy.2011.07.027

Reference yield:

: 91142-84-6
2-[2-(2-oxopropyl)phenyl]acetic acid

: 1340590-02-4
(3R,6R,11aS)-6-ethyl-11a-methyl-3-phenyl-2,3,11,11a-tetrahydro[1,3]oxazolo[2,3-b][3]benzazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 120 °C / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 °C / Inert atmosphere

With lithium hexamethyldisilazane; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetasy.2011.07.027