diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

Base Information

Chemical Name:diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate
CAS No.:1113027-15-8
Molecular Formula:C₃₄H₄₆NO₉PS
Molecular Weight:675.78
Hs Code.:

Synonyms:diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

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Technology Process of diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

There total 1 articles about diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1113027-13-6
diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-3-aza-4acarba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

: 124-63-0
methanesulfonyl chloride

: 1113027-15-8
diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.tet.2008.11.035

Reference yield: 52.0%

: 1113027-15-8
diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

: 127-09-3
sodium acetate

: 1113027-17-0
diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-acetyl-3-aza-4a-carba-β-L-glycero-pentofuranos-3-ylmethyl)phosphonate

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 6h;
DOI:10.1016/j.tet.2008.11.035

Reference yield: 40.0%

: 1113027-15-8
diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate

: 10310-21-1
2-amino-6-chloropurine

: 1113027-34-1
diisopropyl 1-(2-amino-6-chloropurin-9-yl)-5-O-dimethoxytrityl-1,2,3-trideoxy-3-aza-4a-carba-β-L-glycero-pentofuranos-3-ylmethylphosphonate

Guidance literature:: 2-amino-6-chloropurine; With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.333333h;

diisopropyl (2,3-dideoxy-5-O-dimethoxytrityl-1-O-methanesulfonyl-3-aza-4a-carba-α-L-glycero-pentofuranos-3-ylmethyl)phosphonate; In N,N-dimethyl-formamide; at 110 ℃; for 4h;
DOI:10.1016/j.tet.2008.11.035