methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

Base Information

Chemical Name:methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate
CAS No.:1233249-95-0
Molecular Formula:C₂₈H₂₆N₂O₃
Molecular Weight:438.526
Hs Code.:

Synonyms:methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

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Chemical Property of methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

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Technology Process of methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

There total 10 articles about methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233249-93-8
4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoic acid

: 64-04-0
phenethylamine

: 1233249-95-0
methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

Guidance literature:: With 1-hydroxy-1H-benzotriazol hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 20 ℃; for 3h;

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1233249-95-0
methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

1.2: 2 h / 60 °C

1.3: pH 5

2.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

3.2: 3 h / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

4.2: pH 5 / Cooling with ice

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / 3 h / 20 °C

With oxalyl dichloride; 1-hydroxy-1H-benzotriazol hydrate; water; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1233249-95-0
methyl (1-{4-[(2-phenyl ethyl)carbamoyl]benzyl}isoquinolin-4-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 1.17 h / 60 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

2.2: 2 h / 60 °C

2.3: pH 5

3.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

3.2: pH 5

4.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

4.2: 3 h / Cooling with ice

5.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

5.2: pH 5 / Cooling with ice

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-1H-benzotriazol hydrate / 3 h / 20 °C

With oxalyl dichloride; 1-hydroxy-1H-benzotriazol hydrate; water; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;